Quotation from: Manual of Surgery

Written by: Alexander Miles and Alexis Thomson


#Pneumococcal affections of joints#, the result of infection with the
pneumococcus of Fraenkel, are being met with in increasing numbers. The
local lesion varies from a _synovitis_ with infiltration of the synovial
membrane and effusion of serum or pus, to an _acute arthritis_ with
erosion of cartilage, caries of the articular surfaces, and
disorganisation of the joint. The knee is most frequently affected, but
several joints may suffer at the same time. In most cases the joint
affection makes its appearance a few days after the commencement of a
pneumonia, but in a number of instances, especially among children, the
lung is not specially involved, and the condition is an indication of a
generalised pneumococcal infection, which may manifest itself by
endocarditis, empyema, meningitis, or peritonitis, and frequently has a
fatal termination. The differential diagnosis from other forms of
pyogenic infection is established by bacteriological examination of the
fluid withdrawn from the joint. The treatment is carried out on the same
lines as in other pyogenic infections, considerable reliance being
placed on the use of autogenous vaccines.

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