Quotation from: Manual of Surgery

Written by: Alexander Miles and Alexis Thomson

On the inner surface of the skull, the formation of gummatous tissue may
cause pressure on the brain and give rise to intense pain in the head,
Jacksonian epilepsy, or paralysis, the symptoms varying with the seat
and extent of the disease. The cranial nerves may be pressed upon at the
base, especially at their points of exit, and this gives rise to
symptoms of irritation or paralysis in the area of distribution of the
nerves affected.