Quotation from: Manual of Surgery

Written by: Alexander Miles and Alexis Thomson

SYPHILITIC DISEASE

Syphilitic affections of bone may be met with at any period of the
disease, but the graver forms occur in the tertiary stage of acquired
and inherited syphilis. The virus is carried by the blood-stream to all
parts of the skeleton, but the local development of the disease appears
to be influenced by a predisposition on the part of individual bones.