Quotation from: Manual of Surgery

Written by: Alexander Miles and Alexis Thomson


When foci of suppuration have been scattered up and down the medullary
cavity, and the bone has died in patches, several sequestra may be
included by the new case; each portion of dead bone is slowly separated,
and comes to lie in a cavity lined by granulations.


Even at a distance from the actual necrosis there is formation of new
bone by the marrow; the medullary canal is often obliterated, and the
bone becomes heavier and denser--sclerosis; and the new bone which is
deposited on the original shaft results in an increase in the girth of
the bone--hyperostosis.

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