Quotation from: Manual of Surgery

Written by: Alexander Miles and Alexis Thomson


_Pathology._--The disease commences and is most intense in the marrow of
the ossifying junction at one end of the diaphysis; it may commence at
both ends simultaneously--_bipolar osteomyelitis_; or, commencing at one
end, may spread to the other.


The changes observed are those of intense engorgement of the marrow,
going on to greenish-yellow purulent infiltration. Where the process is
most advanced--that is, at the ossifying junction--there are evidences
of absorption of the framework of the bone; the marrow spaces and
Haversian canals undergo enlargement and become filled with
greenish-yellow pus. This rarefaction of the spongy bone is the earliest
change seen with the X-rays.

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