Quotation from: Manual of SurgeryWritten by: Alexander Miles and Alexis Thomson |
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In certain diseases, such as rickets and inherited syphilis, and in developmental anomalies such as achondroplasia, _dwarfing_ of the skeleton results from defective growth of bone at the ossifying junctions. Conversely, excessive growth of bone at the ossifying junctions results in abnormal height of the skeleton or _giantism_ as a result, for example, of increased activity of the pituitary in adolescents, and in eunuchs who have been castrated in childhood or adolescence; in the latter, union of the epiphyses at the ends of the long bones is delayed beyond the usual period at which the skeleton attains maturity.
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