Quotation from: Manual of Surgery

Written by: Alexander Miles and Alexis Thomson


The _nerves_ enter the marrow along with the arteries, and, being
derived from the sympathetic system, are probably chiefly concerned with
the innervation of the blood vessels, but they are also capable of
transmitting sensory impulses, as pain is a prominent feature of many
bone affections.


It has long been believed that _the function of the periosteum_ is to
form new bone, but this view has been questioned by Sir William Macewen,
who maintains that its chief function is to limit the formation of new
bone. His experimental observations appear to show that new bone is
exclusively formed by the cellular elements or osteoblasts: these are
found on the surface of the bone, lining the Haversian canals and in the
marrow. We believe that it will avoid confusion in the study of the
diseases of bone if the osteoblasts on the surface of the bone are still
regarded as forming the deeper layer of the periosteum.

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