Quotation from: Manual of SurgeryWritten by: Alexander Miles and Alexis Thomson |
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In a considerable proportion of cases one of the multiple tumours takes on the characters of a malignant growth ("secondary malignant neuroma," Garre). This malignant transformation may follow upon injury, or on an unsuccessful attempt to remove the tumour. The features are those of a rapidly growing sarcoma involving a nerve-trunk, with agonising pain and muscular cramps, followed by paralysis from destruction of the nerve fibres. The removal of the tumour is usually followed by recurrence, so that high amputation is the only treatment to be recommended. Metastasis to internal organs is exceptional.
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