Quotation from: Manual of Surgery

Written by: Alexander Miles and Alexis Thomson


A definitely positive reaction can usually be obtained between the
fifteenth and thirtieth day after the appearance of the primary lesion,
and as time goes on it becomes more marked. During the secondary period
the reaction is practically always positive. In the tertiary stage also
it is positive except in so far as it is modified by the results of
treatment. In para-syphilitic lesions such as general paralysis and
tabes a positive reaction is almost always present. In inherited
syphilis the reaction is positive in every case. A positive reaction may
be present in other diseases, for example, frambesia, trypanosomiasis,
and leprosy.

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