Quotation from: Manual of Surgery

Written by: Alexander Miles and Alexis Thomson


#Angio-sclerotic Gangrene.#--A form of gangrene due to _angio-sclerosis_
is occasionally met with in young persons, even in children. It bears
certain analogies to Raynaud's disease in that spasm of the vessels
plays a part in determining the local death.


The main arteries are narrowed by hyperplastic endarteritis followed by
thrombosis, and similar changes are found in the veins. The condition is
usually met with in the feet, but the upper extremity may be affected,
and is attended with very severe pain, rendering sleep impossible.

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