Quotation from: Manual of Surgery

Written by: Alexander Miles and Alexis Thomson


#Gangrene associated with Spasm of Blood Vessels.#--#Raynaud's Disease#,
or symmetrical gangrene, is supposed to be due to spasm of the
arterioles, resulting from peripheral neuritis. It occurs oftenest in
women, between the ages of eighteen and thirty, who are the subjects of
uterine disorders, anaemia, or chlorosis. Cold is an aggravating factor,
as the disease is commonest during the winter months. The digits of both
hands or the toes of both feet are simultaneously attacked, and the
disease seldom spreads beyond the phalanges or deeper than the skin.

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