Quotation from: Manual of Surgery

Written by: Alexander Miles and Alexis Thomson


Since the days of Celsus (first century A.D.), heat, redness, swelling,
and pain have been recognised as cardinal signs of inflammation, and to
these may be added, interference with function in the inflamed part, and
general constitutional disturbance. Variations in these signs and
symptoms depend upon the acuteness of the condition, the nature of the
causative organism and of the tissue attacked, the situation of the part
in relation to the surface, and other factors.

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